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Anaerobic-Aerobic Process for Pharmaceutical Wastewater Treatment


Pharmaceutical industry Filtration filter elements

Pharmaceutical industry Filtration filter elements play an important role in the processing of pharmaceutical raw materials. The raw materials of pharmaceuticals often need to go through multiple processes, such as dissolution, suspension, extraction, etc. Microorganisms, solid particles, and impurities may be generated during these processes. The filter element can effectively remove these impurities through its fine filter mesh and filter media to ensure the purity and stability of raw materials. 

In addition, wedge wire filter in the pharmaceutical industry is also widely used in the terminal filtration link in the pharmaceutical process. In the final stage of pharmaceutical production, terminal filtration of the liquid medicine is often required to remove microorganisms and other residual impurities. The purpose of terminal filtration is to ensure the microbial safety and long-term stability of the drug product. Through its microporous structure and high-efficiency filtration capacity, the filter element can effectively remove microorganisms and ensure the quality and safety of end products.

Study the main components in pharmaceutical wastewater, analyze the structure of the reactor, and understand the removal effect of anaerobic particles and flocculent sludge in the anaerobic tank on CODcr.

Taking the UASB as an anaerobic reaction device, understand the wastewater treatment process and treatment process, plan the start-up procedure and control procedure, and understand the application load of the treatment device.

After testing, the pH value of pharmaceutical wastewater is 6.5~7.9, and the temperature is between 36~39℃.

The volatile acid in the treated water is 7.5mmol/L, and the maximum volume load of the pharmaceutical wastewater is determined to be 10.22kgCOD/m3.d. After the operating state exceeds the load range, the UASB device will be damaged.

SBR is an aerobic reaction device. During the operation of the device, the operating parameters of this type of device need to be analyzed to determine the optimal operating range. The MLSS concentration was controlled at 4500 mg/L, the DO was 2-4 mg/L, and the CODcr concentration was 2000 mg/L. The pharmaceutical wastewater is treated in accordance with the relevant management regulations in the Comprehensive Wastewater Discharge Standard.

Discussion on pharmaceutical wastewater

1.1 Reasons for the emergence of pharmaceutical wastewater

The demand for medicines in the medical industry has brought good opportunities for the production of medicines, but the production of medicines will lead to a large amount of pharmaceutical wastewater, and the concentration of pharmaceutical wastewater is also determined by the type of medicines and the production process.

The development of the pharmaceutical industry has also generated a large amount of industrial wastewater. The high-concentration wastewater ecological environment has brought serious pollution, wastewater treatment is difficult, and the treatment process is complicated. The pharmaceutical wastewater with the best and most complex treatment process includes organic wastewater, solvent recovery liquid, fermentation waste liquid and waste mother liquor.

1.2 Water quality characteristics of pharmaceutical wastewater

The pharmaceutical industry is constantly developing, the use of pharmaceutical raw materials and production methods are different, and the wastewater treatment process liquid leads to differences in the pollutant content of wastewater. In addition, the amount of organic solvents is large, the biodegradation is difficult, and the salt content is high. It increases the difficulty of treatment of pharmaceutical wastewater.

(1) The CODcr content is high, and the biopharmaceutical wastewater has a wide range of sources, mainly including nutrients, organic purification and extraction, substances, and fermentation residues.

(2) The content of SS is high. Such pollutants usually appear in the culture medium of fermentation substances, and the pollutants contain insoluble lipids and microbial mycelium.

Analysis of the treatment of pharmaceutical wastewater by anaerobic-aerobic process

The quality of wastewater, the structure of the reactor, the removal of CODcr by anaerobic particles and anaerobic flocculent sludge in the anaerobic device were studied. Using UASB anaerobic sludge with high-efficiency purification device, study the reaction principle of the device, the use value of anaerobic particles, control the temperature and operating load of the instrument, consider environmental factors, and calculate the operating parameters of the device.

SBR is an aerobic device for the treatment of pharmaceutical waste liquid, and the operating parameters of the device are the key factors to be considered during the operation of the device. In addition, factors such as ambient temperature and aeration time need to be well controlled.

2.1 Analysis of the treatment process of UASB anaerobic organisms

When treating organic anaerobic compounds in pharmaceutical waste liquid, it is necessary to analyze the composition and structure of organic molecules and the decomposition process, and then complete the subsequent purification operation process.

(1) Hydrolysis, the substances processed in the hydrolysis stage are mainly large-volume molecular substances such as fat proteins, which need to be hydrolyzed to ensure the smooth progress of the subsequent operation process.

(2) Acidification, in the acidification stage, the small molecule organic matter is processed to understand the cell transformation process and the types of fermenting bacteria.

(3) Acetic acid treatment. The acetic acid treatment process is usually used in the acidification stage of substances. In this stage, substances such as butyric acid and propionic acid are decomposed and transformed. At the same time as the formation of microorganisms, new cellular substances are also produced.

2.2 SBR process principle

The activated sludge method is one of the earliest applied pharmaceutical wastewater treatment processes. When using this method, it is necessary to ensure the intermittent operation of activated sludge. Control the operation process of the water inlet cycle and the operation steps of the water body conversion, pay attention to the operation status of the aeration equipment, and determine whether there will be congestion problems.

In the water inlet stage, the water inlet stage is an important stage of sewage treatment. When treating pharmaceutical wastewater at this time, it is necessary to understand the drainage function of the instrument and the idle function of the device. Analyze the sludge concentration and the composition of pollutants in the mixed liquor.

Reaction operation, understand the operation process of the reactor, analyze the biological consumption mechanism and the reaction and consumption process of organic matter, understand the aeration and stirring method, but also analyze the dissolved oxygen conditions in the anaerobic-aerobic process, and do a good job in nitrogen and phosphorus removal. Work.


The treatment of pharmaceutical wastewater is proceeding in an orderly manner, and the anaerobic-aerobic process has significant results in the treatment of pharmaceutical wastewater, which has good application value. my country’s pharmaceutical production industry is constantly developing, and pharmaceutical wastewater treatment technology is also constantly improving. In the future, the effect of anaerobic-aerobic process of pharmaceutical wastewater treatment will be more significant.