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Deep filtration technology in biopharmaceuticals



Filtration products produced by filtration technology are also widely welcomed in the market. Including antibiotics, culture media and other products that we are used to. This paper briefly discusses the application of deep filtration technology in biopharmaceutical process.
People’s living standards have also improved rapidly with the rapid development of the times. People began to hold a higher attitude towards life. Environmental pollution has become a disadvantage brought by the development of science and technology, and the land we live in has been gradually eroded. 
The probability of people getting sick has greatly increased, and the types of diseases evolved are also increasing day by day. This requires our medical level to reach a higher level to ensure people’s health and safety. The biopharmaceutical process is undoubtedly a very important part in this link. Therefore, the modern level of science and technology must develop more effective and guaranteed drugs in medical treatment. The use of deep filtration technology in biopharmaceutical processes has become a paving block for the development of the medical field. 

Deep filtration technology 

With the concept of deep filtration technology, there must be corresponding surface filtration. This division is given because of the different mechanism. These two types of filtration methods have been gradually applied in the biopharmaceutical process industry.  
The filter material for deep filtration is generally composed of fibers. The channels between filter media are usually very tortuous and very long. 

It is precisely because the filtered impurity particles are smaller than the voids in the medium. So the particles will be captured by the filter material in the longitudinal depth. 

Under the dynamic action of thermal motion and fluid. The channel wall will flow some fine impurity particles in the feed liquid, and electrostatic adsorption and surface tension will intercept these impurity particles. 

The corresponding surface filtration is only to arrange uniform aperture on the filter material. And complete relevant work on the surface of the filter material. It is only necessary to arrange uniform aperture on the filter material. 

Due to the different pore size, the filter material will selectively retain the suspended impurity particles required for starting on its surface.  

Development status of biopharmaceutical process in China 

Due to various reasons, our national biopharmaceutical process did not start at an earlier time. We have lost the priority of development, but the speed of development is faster than that of other countries. 

During this period of rapid development, China has developed biopharmaceutical products that have sufficient influence on the market and are highly praised. However, due to the shortage of research funds and the insufficient supply of human resources in the biopharmaceutical industry. So that our scientific achievements can not be put into practical use in the effective time. 

Such a bad operating condition has also led to the long-term interests of this industry in China not being guaranteed. Some students have also shaken their determination to tackle this major. In the long run, it will make China’s biopharmaceutical technology reach the world’s advanced level. 

Application of deep filtration technology in biopharmaceutical process 

Due to the strict requirements on the precision of filter media in the biological pharmaceutical process. The suppliers of filter products can improve the precision by increasing the density of filter material to obtain smaller pore size. However, although this method meets the needs of enterprises for products on the one hand, it has certain disadvantages. 

With the development of science and technology, scientists have found ZETAPLUS filter material through experiments, which has solved the problems caused by pressure difference and flow rate.
There are negative charges in many media of biopharmaceutical process feed. Our usual treatment method is to remove impurities through mechanical filtration and electrostatic adsorption. Particles with larger pore size can be directly removed by mechanical filtration. The particles with smaller pore size can be negatively charged and adsorbed on the resin with positive charge in the environment of lower PH. 

In the actual application process, the deep filter material has positive charge, and the filtration efficiency will be improved to a certain extent.  

Clarification process of fermentation broth  

After the fermentation and the crude separation of the feed liquid, there are still some other impurities in the extracted supernatant. These negatively charged cell fragments and other components can be further processed with ZETAPLUSS. Through the organic interception of unloading and electrostatic adsorption. We have achieved high flux and low pressure drop, and improved product quality. The production process is simplified.  
Therefore, the efficiency has been greatly improved, directly improving the level of our biopharmaceutical process.

Remove excess macromolecular impurities  

Cell debris is a kind of lipopolysaccharide. It is produced by various kinds of bacteria on the outer wall of gram-negative bacteria, with a molecular weight of millions. Such high molecular weight substances will cause great harm to the body.  
In medicine, activated carbon was used to remove these cell fragments by repeated adsorption. However, this method has twice the result with half the effort, and has invested huge human and material resources, but has not received the desired results. 
The deep filtering technology SETAPLU SP is a great progress in this field. Mechanical interception and electrostatic adsorption are used together. The disadvantages of using activated carbon adsorption have been effectively eliminated, and the efficiency of pharmaceuticals has been improved qualitatively. It has saved basic costs and created greater economic benefits. 

Fine extraction process of small molecular substances 

In medicine, there are many drugs with small molecular weight, such as antibiotics. The traditional processing methods are filtration, concentration, crystallization and other physical methods. 

This method has been unable to adapt to the complex and inefficient processing technology with fast pace. The basic problem of insufficient processing accuracy has become a cage for the development of biopharmaceutical technology. 

In ZETAPLUS deep filtration technology, the traditional process can be simplified, and the macromolecular substances in the process feed can be removed by electrostatic adsorption. Simple, fast, more operational, safe and reliable.  

Future development of deep filtration technology in pharmaceutical industry  

The biopharmaceutical industry has played an increasingly important role in society. People rely on the improvement of the level of biopharmaceuticals to protect their lives from the increasingly complex environment. We cannot slow down the pace of progress in biopharmaceutical technology. The biopharmaceutical industry relying on deep filtration technology will also be the main force of future development. We have seen the amazing effect of deep filtration technology in the current development. Time is cost. 

At present, China still mainly relies on learning from foreign advanced technical concepts and production experience. There is a lack of self-innovation, and the lack of high-end talents makes this situation unable to be effectively improved in a short period of time.  
This article focuses on deep filtration. Similarly, surface filtration is also crucial in the pretreatment of biopharmaceuticals. The new generation of wedge wire filters we developed can do this work well.